Life in a small town

Cancer … and the Ketogenic diet …

WooHoo!  The Cancer book arrived today. “This book is dedicated to the millions of people who have suffered and died from toxic cancer therapies“. Just about says it all. From the Amazon.com blurb … “The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention.

It expands upon Otto Warburg’s well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the “hallmarks of cancer” and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requiring metabolic solutions for its management and prevention.

Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.”

Dr. Thomas N. Seyfried

Dr. Thomas N. Seyfried

And from the back cover … “Supported by evidence from more than 1,000 scientific and clinical studies, this groundbreaking book demonstrates that cancer is a metabolic disease and, more importantly, that it can be more effectively managed and prevented when it is recognized as such.

Moreover, the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible  for the failure to develop effective therapies and preventive strategies.

From the abstract of the article found here  at the U.S. National Library of Medicine I highlight and quote the connection to what this book is about and the Ketogenic diet as follows : “Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation.

The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The disturbances in tumor cell energy metabolism can be linked to abnormalities in the structure and function of the mitochondria.

When viewed as a mitochondrial metabolic disease, the evolutionary theory of Lamarck can better explain cancer progression than can the evolutionary theory of Darwin. Cancer growth and progression can be managed following a whole body transition from fermentable metabolites, primarily glucose and glutamine, to respiratory metabolites, primarily ketone bodies.  (this is the connection I want to shine light on between the Ketogenic diet and cancer prevention and treatment.)

As each individual is a unique metabolic entity, personalization of metabolic therapy as a broad-based cancer treatment strategy will require fine-tuning to match the therapy to an individual’s unique physiology.”

As previously posted relating to standards and guidelines, “we are all outliers” unique individuals and there is no “standard Human” to which standards and guidelines apply. Standards and guidelines are created and enforced for the convenience of practitioners and administrators, not people and patients.

It is my personal belief that the “authorities” don’t care if the “guidelines and standards” kill a few hundred thousand patients as long as they can’t be blamed, their well ordered universe is not disturbed and the gravy train is not derailed.

I am not for a minute suggesting individual personal intent in any of this. But we all want to belong to the “In Crowd”, the “right clique”, we all love ourselves and want to think of ourselves as knowing better than the rest of the mob. Peer pressure is a truly diabolical power especially amongst “professionals” whose very livelihood depends on “being on the approved list”.

My 65 years of observation seem to show that humanity is almost universally happy to ignore “truth” and “provable facts” in support of their personal “fantasy”. This is obvious with just a cursory look at everything put out by mainstream media these days.

The current “political” and “economic”polarization of our society bears daily witness to this fact. This problem with “truth” and “provable facts” is especially obvious if “truth” and “provable facts” hurt their chosen fantasy du jour, and becomes a virtual certainty if the fantasy improves their own lot in life.

The short story is we cannot live on bread alone, or cake, or candy, or rice and potatoes or a danish and a latte. We all require fine-tuning (of our diets) to match our life therapy to each individual’s unique physiology. and we cannot live without fat.

Culturally our society appears to be willingly killing ourselves with a diet high in glucose producing carbohydrates because we love our breads, sugars and starches, and we love them enough to try to eat them 6 or 8 times a day.

Many of us have become so metabolically deranged working our glucose metabolism 24/7 365 days a year that our mechanism for safely metabolising glucose has become broken – and that is how we got type 2 diabetes, and a host of other killers like cancer. “Let them eat cake” may be historically inaccurate, but it does seem to be a death sentence for us today.

Those kinds of foods are very cheap to produce and have a very high profit margin. The drugs that our current medical model prescribes to treat the resulting diseases of a cheap high carbohydrate diet have little effect in reversing and curing our current crop of medical killers and many actually create worse problems going forward.

2 Keto Dudes

2 Keto Dudes

As the 2 Keto Dudes say: “We can, however, hack our body into being full time fat burners. This hack not only allows us to maintain safe glucose levels (http://www.ncbi.nlm.nih.gov/pubmed/19099589), with less medication (http://www.ncbi.nlm.nih.gov/pubmed/25071075), but improves many of our biomarkers of disease.

If we additionally choose to use this hack to also lose weight it preserves more of our our resting energy expenditure (http://jama.jamanetwork.com/article.aspx?articleid=1199154) and over time if we have intervened early enough can allow us to reverse the progression of type 2 diabetes (http://www.yorku.ca/mriddell/documents/istype2reversible.pdf).

This dietary strategy is still something that Diabetes Associations around the world are only just now looking at, and Dietetic associations are firmly opposed to, as it is not a modest tweak of their established food pyramid, but a complete upending of it.

There are political issues as well. The USDA has a conflict of interest when it comes to dietary guidelines. That said, the ketogenic diet is quickly becoming the first approach in diabetes management among progressive medical specialists (http://www.nutritionjrnl.com/article/S0899-9007(14)00332-3/pdf).

The bottom line for us is that following the low fat model for the past 40 years has made us fatter and sicker.”

Much more to follow as I delve into this fascinating area.

Cheers

Joe

So much to study … so much to share …

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