Life in a small town

More on Cancer and Glucose … cancer and respiration …

Kojo No Tsuki” (Rentaro Taki), performed by Yo-Yo Ma, Michio Mamiya, & Patricia Zander, from the album “Japanese Melodies” (1990)

My interest in following up on “Cancer as a Metabolic Disease” is the preponderance of evidence suggesting that Cancer flourishes in a glucose rich bodily environment. Our modern western culture’s generally accepted wisdom on diet and medical care inevitably produces a glucose rich bodily environment.

Coincidentally, we seem to be experiencing an epidemic of cancer of all types with very little success in treating same with conventional treatment models. This nutritional, and medical model and the academic research interests related to these  models appear to have produced the highest disease rates for certain deadly diseases, and the lowest cure rates for those same diseases, in history. (IMAO, opinion only, not validated by research)

At the same time we have witnessed the development and proliferation of the most prestigious, prosperous and profitable sectors of health care, nutrition, government, and academia in Western history. These sectors’ prosperity is underlain by government’s ability to fund, through the use of “public” moneys, their preferred directions and interests in research, health care delivery, and manufacturing, ostensibly in the interest of “public” health, the largest sector by far of all government spending outside of compensation and benefits for government workers and management.

In nations lacking a prosperous “private” economy there is significantly less budget, less personnel at all levels, and significantly less staff and management compensation directed at these sorts of policy targets. This Western tapestry of interrelated sectors and interests is simply too large to be seriously considered as any sort of conspiracy of players, at least too large to be a human conspiracy.

Dr. Thomas N Seyfried,

Dr. Thomas N Seyfried,

However, it is hard to deny that fundamental to these developments is the modern religion of self, our modern culture of narcissism and self worship, our propensity to pursue personal prosperity and to exhibit “Me First” behaviour.

This critical conjunction of “self interest” makes it hard to imagine a better way of anonymously destroying humanity than what we are seeing taking place all around us at this time in our history.

Going along with this behaviour is a sense of: “let the “masses” look after themselves, unless there is a prospect of making revenue off them … what’s in it for me?”. Then self interest takes over as authority systems direct others … “for their own good”.

Stay on track, Joe! I have to remind myself that this is not about what is wrong and how “I” have to fix it. I have to remember that the inner struggle is about turning the sword of the imagination inward, to cut out the inner faults and bad habits, and not to turn outward to destroy the obvious evils without. Why is the default still to point out what is wrong “out there” when there is so much wrong “in here”?

So, what have I understood after getting through the first two chapters of “Cancer as a Metabolic Disease“? Well, … first of all I am always a sucker for detailed bibliographies and cited references. Here are the references pages for just Chapter 2. You can click on the images to get a larger version in another window if these are too small to read. The snippets follow …

So what have I gleaned from Chapter 1 and 2, well, here goes …

First, it became clear to me that the therapeutic action of some anticancer drugs operated largely through reduced caloric intake. Second, that reduced caloric intake could target the majority of cancer hallmarks. Third, that ketone bodies can serve as an alternative fuel to glucose in most cells with normal respiratory function. …” (Cancer as a Metabolic Disease, pp XV)

So my takeaway from this snippet is that following a carbohydrate reduced (and thus a glucose reduced), ketogenic, fat based diet, reduces the presence of glucose and increases the presence of ketone bodies, and that is good for overall health, but especially in reducing the propensity for development of cancer.

Many of the current cancer treatments exacerbate tumor cell energy metabolism, thus allowing the disease to progress and eventually become unmanageable. … The view of cancer as a genetic disease has confounded the problem and is largely responsible for the failure to develop effective therapies. The view of cancer as a genetic disease is based on the flawed notion that somatic mutations (gene mutations) cause cancer. Substantial evidence indicates that genomic instability is linked to protracted respiratory insufficiency. (ie. caused by damage to the metabolic process of cell respiration) (Cancer as a Metabolic Disease, pp XV).

In addition to the six recognized hallmarks of cancer, aerobic fermentation, or the Warburg effect is also a robust metabolic hallmark of most tumors whether they are solid or blood born. Aerobic fermentation involves elevated glucose uptake with lactic acid production in the presence of oxygen.  Elevated glucose uptake with lactic acid production is a defining characteristic of most tumors and is the basis of tumor imaging using labeled glucose analogs. … nearly all tumors depend heavily on glucose for survival.

Again, my takeaway from this is the necessity of a glucose rich environment for cancer to flourish. A ketogenic diet limits glucose levels in the body and effectively limits the possibility of cancer developing through controlling the production of glucose. Also, it is common knowledge in research circles that gene mutation is quite rare amongst healthy cells and certainly not even remotely prevalent enough to account for all the different cancers we are witnessing in the general population these days.

On the other hand, gene mutation as a result of damage to the metabolic process of cell respiration easily accounts for the frequency of cancer in all populations. It appears that the current model has the cart before the horse. It seems that there must be some other mechanism at work to support the cancer industry’s fascination with gene mutation as the primary cause of cancer.

Cancer Statistics ...

Cancer Statistics … from Cancer as a Metabolic Disease, pp 12 Chapter 1

“… Just as there are many causes of plague — heat, insects, rats, — but only one common cause, the plague bacillus, (so) there are many causes of cancer — tar, rays, arsenic, pressure, urethane, — but there is only one common cause into which all other causes of cancer merge, the irreversible injuring of respiration. An increased dependence on energy through glucose fermentation (glycolysis) was viewed as an essential compensatory mechanism of energy production for cell vitality following damage to respiration. … Warburg proposed with insight and certainty that irreversible damage to (cell) respiration was the prime cause of cancer.”

” … James Watson, who co-discovered DNA as genetic material with Francis Crick in 1953, recently suggested that more attention be paid to the metabolism of cancer. Watson also believes that the direction of cancer research in the United States is largely offtrack and misdirected at the highest levels. The absence of major clinical breakthroughs in the cancer war over the last 40 years and the death statistics … support Watson’s contention.

… the Warburg effect can be linked to impaired respiration and energy metabolism … respiratory insufficiency precedes and underlies the genome instability that accompanies tumor development. Once established, genome instability contributes to further respiratory impairment, genome mutability, and tumor progression.”

” I contend that most of the gene defects in natural cancers arise as downstream effects of damages mitochondrial function. (mitochondria are the cell organelles which enable cellular respiration). My hypothesis (Seyfried’s hypothesis) is based on evidence that genome integrity is largely dependent on the cell having sufficient mitochondrial respiration, and that all cells require regulated energy homeostasis to maintain their differentiated state.”

And thus endeth chapter the second. … more to follow as I dig deeper into this dense book.

Cheers

Joe

Rise Up

Rise Up

One of the things life has shown me is that whenever the majority of the chattering classes and the media and the academics and the government wonks are busy saying something is so, that is an almost certain indicator that it is NOT so — being on the wrong side of history is THE defining characteristic of all those opinion makers.

Standard
Life in a small town

Cancer … some more information.

From the beginning of the book  “Cancer as a Metabolic Disease …”.

… A key point made by Seyfried (Dr. Thomas Seyfried) is that most of the genomic instability seen in cancer likely arises as a consequence rather than as a cause of the disease. When viewed more as a metabolic disease, many cost effective therapeutic strategies become recognized for cancer management.

I know this first hand from our studies of 3-bromopyruvate (3BP) discovered in my laboratory by Dr. Young Ko, as a potent anticancer agent. This is a low cost drug with powerful and quick antitumor effects against multiple cancers in animal models and in cancer patients.

3BP works primarily by targeting tumor cell energy metabolism, thus depleting the energy-rich compound “ATP” essential for growth. At the effective doses used, it does this without toxicity to normal cells. 

Seyfried’s book provides substantial evidence showing how cancer can be managed using various other drugs and diets that target energy metabolism. In addition, the restriction of glucose and glutamine, which drive cancer energy metabolism, cripples the ability of cancer cells to replicate and disseminate.

Dr. Peter Pedersen

Dr. Peter Pedersen

The gene theory has deceived us into thinking that cancer is more than a single disease.” (from the Forward, by Dr. Peter Pedersen, Professor of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD)

We should note that a blog site “Science” for the magazine of the same name, reported in 2016 the following event:

“A new type of cancer drug developed at Johns Hopkins University in Baltimore, Maryland, but not yet tested in clinical trials may have triggered the deaths of three patients who were undergoing an alternative cancer treatment by a non-medical practitioner in Germany. Germany has many such practitioners, and the field is loosely regulated. The public prosecutor in Germany is now investigating whether the case constitutes involuntary manslaughter.

The drug in question, 3-Bromopyruvate (3BP), has been hailed by some researchers as a potential breakthrough, but so far the only human data about its efficacy and safety are anecdotal. Many scientists say the drug should not be administered to patients except in carefully controlled experimental settings. If the link to the three deaths is confirmed, that could cloud 3BP’s commercial prospects.”

Read the rest here.

So one might question who funds “Science” magazine. What kind of advertising do they sell? What kinds of grants do they get and from who? My take on this bad report goes like this:

Two other patients had to be treated for life-threatening conditions, the prosecutor’s office said in a press release today. Police in Germany, the Netherlands, and Belgium have urged other patients treated at the center to contact local health authorities; at least 26 have done so. Media reports suggest that cancer patients often sought Ross’s help after they ran out of conventional therapy options, or to avoid aggressive chemotherapy.”

So the patients in question had exhausted all other conventional forms of treatment. Let’s think about this situation for a minute. Unconventional 3BP treatment is linked to the deaths of 3 patients and 2 other life-threatening illnesses, … in terminal cancer patients … hmmm.

But looked at without any bias or interest, conventional chemo therapy and radiation therapy and surgery result in the eventual death of a high 90%s of all cancer patients.

Broad brushed like our MSM and popular “Science” journals like to do might lead one to look at the headline

” Candidate cancer drug suspected after death of three patients at an alternative medicine clinic. “

which inevitably leads uninformed patients towards Fear Uncertainty and Doubt, the three horsemen of the journalistic apocalypse, by which dieing people are threatened about straying off the reservation.

But with a slight adjustment and reporting of actual statistical data the same headline might read:

” Cancer drugs and Radiation Therapy suspected in death of millions of cancer patients at Private and Government Health Care Centers worldwide”

and take patients down a completely different path. That path might include a serious danger of derailing the gravy train for conventional practitioners and organizations.

There are provably more reliable statistics to support the second headline than the first, but what we hear about is the three deaths and not the millions. One is inevitably drawn to the question, yet again, of media bias and motivations.  Who are the paid shills for the establishment in this scenario?

Here is another article on 3BP

Dr Young Ko

Dr Young Ko

And this is how things went for Dr. Ko

*****

“Cancer cure found by Dr Young Ko at JHU – 3-bromopyruvate 70c per day to treat people

This is what happens to anyone who claims to have had successful research into cancer cures. Dr Ko has been sacked and her research is being “undertaken” by other scientists.

Seven years after her initial discoveries, there are no clinical trials under way, nor are there any (that I could find) that will commence any time soon. Instead, what scientists are trying to do is to make synthetic 3-bromopyruvate analogs that can be patented (and thus much more valuable).

So here we have a detour that will take years of extra research and development in order to maximize profits, while the dirt cheap, off-the-shelf chemical that could be helping people NOW gets tossed aside because it can’t be patented by a pharmaceutical company.

John’s Hopkins destroyed Dr. Ko’s career supposedly for publishing her results on 3-bromopyruvate too soon and with too much hype. Now science is proving her to be right.

Not only that, but by almost single-handedly reviving the dead concept of cancer energetics (killing cancer cells by depriving them of their unique energy needs) Dr. Ko may have made the most important single breakthrough in cancer treatment research in decades.

After destroying her for this, they now have the gall to patent her work (and under different researcher’s names). However she is taking them to court. I cant find any updates however since about 2007.”

*****

Well, one thing for sure, “Cancer as a Metabolic Disease …”. has turned into an interesting and provocative read, and there I thought it would be like reading a 4th year bio-chem textbook. Who knew?  Curiouser and curiouser …

Just thinking about it.

Your mileage may vary …

Cheers

Joe

 

Standard
Life in a small town

Cancer as a Metabolic Disease …

In between bouts of accounting, and IT frustration, I am recreating by reading “Cancer as a Metabolic Disease …”.

It is heavy going but understandable, and both discouraging in its recounting of the past 50 years and very encouraging of the fasting Keto lifestyle. I will post snippets here and there when I find stuff clearly relevant to fasting and Keto, but for starters, from the Forward (by Dr. Peter Pedersen, Professor of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD):

Cancer persists as a major disease of mortality and is afflicting more people today than ever before. Few families remain untouched by this insidious and vicious disease. In fact, cancer is predicted to overtake heart disease as the prime cause of death in industrialized societies during this century (21st). … The Nobel laureate, Otto Warburg, was the first to provide evidence during the early part of the last century for the involvement of disturbed respiration with compensatory fermentation (glycolosis) as a common property of cancer, thus perceived to be related to its uncontrolled growth and progression. Few subjects have been as controversial in the cancer field as Otto Warburg and his theory of cancer. … “

and

The cancer field went seriously off course during the mid-1970s when many investigators began considering cancer as primarily a genetic disease rather than a metabolic disease. The metabolic defects in cancer cells were thought to arise as secondary consequences of genomic instability. Seyfried provides substantial evidence documenting the inconsistencies of the gene “only” theory.”

So this is way more enjoyable than following the daily news about Justin’s latest faux pas. I am just an opinion writer, a punter, a speculator, I have no hard evidence of malfeasance or malice. I have not done any actual research myself, I am simply reading about the work of others. But this is not my first rodeo, and a thorough knowledge of secular human nature based on 30 years experience in the Military, Corrections, and Government Health Care, has taught me that, absent genuine concern (aka Charity, or Love Agape) for the well-being of other people, we as humans often go to a dark, self centered place.

My cynical “opinion” (just an opinion piece, folks)  is that the scientific and pharmaceutical community have had the solid evidence about cancer as a metabolic disease right in front of them for a hundred years now and have chosen intentionaly to ignore that evidence and go down the rabbit hole of genetic causes and pharmaceutical solutions. Why?

Could it be that there are orders of magnitude of more rewards and resources to be had in genetic research and pharmaceuticals than in treating metabolic disease with inexpensive and effective dietary solutions? I have witnessed the path of cancer research as being a mighty gift that keeps on giving for my entire adult life, but none of that gift gravy train has accrued to the patients, the actual victims of cancer.

All of the billions in this gravy train disappear into the voracious mouths and pockets of academic researchers, pharmaceutical companies and government health departments. Again, who knows about motives and intentions? No one but God can know that stuff.  I don’t  believe this thought as a provable, “admissible in a courtroom” fact, it just looks like this might be one explanation which accounts for all the observed actions and results. Judgements about intentions and direction are outside our realm of knowledge.

We went to the moon, from zero to landing, in one decade. Where are the miracle cures and happy endings that these 5 decades of work and  billions of dollars should produce? We have been lavishing the lion’s share of our health resources on silos of executive remuneration and cancer research for nearly 50 years now and where are the results that all this effort should have been producing?

None! Nada! No cures or happy endings. Just toxic drugs and cruel surgery, whole libraries of distracting publicity and propaganda, and millions of dieing patients who are bankrupted in the course of their hopeless quest for a cure. Every run for cancer, every yellow daffodil, every Terry Fox clone, every publicity and media event are all about “MORE MONEY” for the “War on Cancer”.

All of these resources just disappear every year now for 50 years with no clear and open accounting and no results. It is all the secrecy and cover-up that provokes the curiosity about Who, What, When, Where, and Why, but you will never see anything about this in the mainstream media even though this is touted as their main job and responsibility, nah they would much rather go after The Donald on social media, than do real journalism. Can one even conceive of our national propaganda ministry, the Holy CBC, ever biting the hands that feed it? Are there bears in the forest? Is the Pope Catholic?  No, no, wait a minute, that’s for another post.

There have been chillingly few victories in this never ending war, a war that we are provably loosing every day. But the big winners in this tawdry melodrama are never the victims, the dieing patients and suffering families.

Think about it …

Cheers

Joe

 

Standard
Life in a small town

Cancer … and the Ketogenic diet …

WooHoo!  The Cancer book arrived today. “This book is dedicated to the millions of people who have suffered and died from toxic cancer therapies“. Just about says it all. From the Amazon.com blurb … “The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention.

It expands upon Otto Warburg’s well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the “hallmarks of cancer” and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requiring metabolic solutions for its management and prevention.

Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.”

Dr. Thomas N. Seyfried

Dr. Thomas N. Seyfried

And from the back cover … “Supported by evidence from more than 1,000 scientific and clinical studies, this groundbreaking book demonstrates that cancer is a metabolic disease and, more importantly, that it can be more effectively managed and prevented when it is recognized as such.

Moreover, the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible  for the failure to develop effective therapies and preventive strategies.

From the abstract of the article found here  at the U.S. National Library of Medicine I highlight and quote the connection to what this book is about and the Ketogenic diet as follows : “Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation.

The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The disturbances in tumor cell energy metabolism can be linked to abnormalities in the structure and function of the mitochondria.

When viewed as a mitochondrial metabolic disease, the evolutionary theory of Lamarck can better explain cancer progression than can the evolutionary theory of Darwin. Cancer growth and progression can be managed following a whole body transition from fermentable metabolites, primarily glucose and glutamine, to respiratory metabolites, primarily ketone bodies.  (this is the connection I want to shine light on between the Ketogenic diet and cancer prevention and treatment.)

As each individual is a unique metabolic entity, personalization of metabolic therapy as a broad-based cancer treatment strategy will require fine-tuning to match the therapy to an individual’s unique physiology.”

As previously posted relating to standards and guidelines, “we are all outliers” unique individuals and there is no “standard Human” to which standards and guidelines apply. Standards and guidelines are created and enforced for the convenience of practitioners and administrators, not people and patients.

It is my personal belief that the “authorities” don’t care if the “guidelines and standards” kill a few hundred thousand patients as long as they can’t be blamed, their well ordered universe is not disturbed and the gravy train is not derailed.

I am not for a minute suggesting individual personal intent in any of this. But we all want to belong to the “In Crowd”, the “right clique”, we all love ourselves and want to think of ourselves as knowing better than the rest of the mob. Peer pressure is a truly diabolical power especially amongst “professionals” whose very livelihood depends on “being on the approved list”.

My 65 years of observation seem to show that humanity is almost universally happy to ignore “truth” and “provable facts” in support of their personal “fantasy”. This is obvious with just a cursory look at everything put out by mainstream media these days.

The current “political” and “economic”polarization of our society bears daily witness to this fact. This problem with “truth” and “provable facts” is especially obvious if “truth” and “provable facts” hurt their chosen fantasy du jour, and becomes a virtual certainty if the fantasy improves their own lot in life.

The short story is we cannot live on bread alone, or cake, or candy, or rice and potatoes or a danish and a latte. We all require fine-tuning (of our diets) to match our life therapy to each individual’s unique physiology. and we cannot live without fat.

Culturally our society appears to be willingly killing ourselves with a diet high in glucose producing carbohydrates because we love our breads, sugars and starches, and we love them enough to try to eat them 6 or 8 times a day.

Many of us have become so metabolically deranged working our glucose metabolism 24/7 365 days a year that our mechanism for safely metabolising glucose has become broken – and that is how we got type 2 diabetes, and a host of other killers like cancer. “Let them eat cake” may be historically inaccurate, but it does seem to be a death sentence for us today.

Those kinds of foods are very cheap to produce and have a very high profit margin. The drugs that our current medical model prescribes to treat the resulting diseases of a cheap high carbohydrate diet have little effect in reversing and curing our current crop of medical killers and many actually create worse problems going forward.

2 Keto Dudes

2 Keto Dudes

As the 2 Keto Dudes say: “We can, however, hack our body into being full time fat burners. This hack not only allows us to maintain safe glucose levels (http://www.ncbi.nlm.nih.gov/pubmed/19099589), with less medication (http://www.ncbi.nlm.nih.gov/pubmed/25071075), but improves many of our biomarkers of disease.

If we additionally choose to use this hack to also lose weight it preserves more of our our resting energy expenditure (http://jama.jamanetwork.com/article.aspx?articleid=1199154) and over time if we have intervened early enough can allow us to reverse the progression of type 2 diabetes (http://www.yorku.ca/mriddell/documents/istype2reversible.pdf).

This dietary strategy is still something that Diabetes Associations around the world are only just now looking at, and Dietetic associations are firmly opposed to, as it is not a modest tweak of their established food pyramid, but a complete upending of it.

There are political issues as well. The USDA has a conflict of interest when it comes to dietary guidelines. That said, the ketogenic diet is quickly becoming the first approach in diabetes management among progressive medical specialists (http://www.nutritionjrnl.com/article/S0899-9007(14)00332-3/pdf).

The bottom line for us is that following the low fat model for the past 40 years has made us fatter and sicker.”

Much more to follow as I delve into this fascinating area.

Cheers

Joe

So much to study … so much to share …

Standard
Life in a small town

Diet, Micro-nutrients, and Health … Part Five Cancer & Ageing & other stuff …

Snow”, by Kobudo, from the album “Ototabi”  (2013)

Continuing in my series of posts, an overview of what I have found about nutrition and diet over the last 15 months or so, information sources which I have found helpful. As mentioned, your mileage may vary but my goal is to stay healthy, happy, and maybe get wise if I live long enough.  Anyway …

2 Keto Dudes

2 Keto Dudes

Well, life is interesting. I am excited by what I have been reading about the work of Dr. Thomas N. Seyfried at Boston College. First  we take a listen to one of the “2 Keto Dudes” podcasts featuring Dr. Seyfried. It is found at  http://2ketodudes.com/show.aspx?episode=113

This got me so excited that I immediately followed up on Thomas N. Seyfried at Boston College, found at:

https://www.bc.edu/bc-web/schools/mcas/departments/biology/people/faculty-directory/thomas-seyfried.html

Thomas N. Seyfried

Thomas N. Seyfried

Dr. Seyfried’s research program focuses on mechanisms by which metabolic therapy manages chronic diseases such as epilepsy, neurodegenerative lipid storage diseases, and cancer. The metabolic therapies include caloric restriction, fasting, and ketogenic diets.

Dr. Seyfried’s approach is based on the idea that compensatory metabolic pathways are capable of modifying the pathogenesis of complex diseases. Global shifts in metabolic environment can neutralize molecular pathology. In the case of cancer, these therapies target and kill tumor cells while enhancing the physiological health of normal cells.

The neurochemical and genetic mechanisms of these phenomena are under investigation in novel animal models and include the processes of inflammation, cellular physiology, angiogenesis, and lipid biochemistry.

Dr. Seyfried published a groundbreaking treatise entitled, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley, 1st ed., 2012). The treatise provides extensive information showing that cancer can be best defined as a mitochondrial metabolic disease rather than as a genetic disease.

This new concept has implications for the development of new non-toxic cancer therapies including the ketogenic diet. Experts in the cancer research field have praised this comprehensive study as one of science’s hottest topics. Amazon customer reviews.

Of the 10 pages of reviews, about 75% are 5 Stars. *****. That is extremely good for a high end medical book which requires significant neurons firing to make headway.

I have to say a little to the negative reviewers. First of all, it is well known that one can’t please everyone and no matter how good the message there are some humans who will find something to bitch about no matter who you are or what you are saying. Look what happened to Jesus Christ, the most perfect Man who ever lived.

As usual, there are always a few panning the book for all the usual reasons – like “It’s too expensive“,, “He is just pushing his diet“, “I didn’t think of this first, Oh Wah!” and so on. In this case I suspect that virtually all the negative reviews are from people who were looking for an authority which agreed with them, or were looking for a quick and easy fix for their particular problem.

For all those reviewers you have the whole established medical paradigm to fall back on. Hope that works for you. I would bet a good Keto meal that most of these nay-sayers never actually read the book all the way through but gave up as soon as the going got tough.

But death is a tough route … cancer sucks BIG TIME … so go with your feelings and see if the genetic cancer model, and radiation, and chemo works for you … who knows, you might get lucky and be cured without having to change your thinking.

I quote just one review here:

*****

“Cancer is an illness that directly or indirectly affects most people at one time or another. Thus, my interest in this book was motivated by a desire to learn more about recent advances in the treatment of the disease and the success that has been achieved especially in recent years with the well chronicled revolution in “precision medicine” and its underlying application of gene therapy.

However, I was stunned and somewhat disheartened to learn of the slow rate of progress in the treatment of cancer in spite of the monumental financial investment and the efforts of so many scientists and other professionals in universities, medical schools, and in the pharmaceutical industry.

As so powerfully and effectively described by the author of this book, slow progress in the “war on cancer” lies not only in the complexity of the disease itself, but also, and perhaps more importantly, on the non-universal recognition of some of the most basic and fundamental aspects of the cause of cancer.

The author takes the position that cancer is a metabolic disease, following up on the pioneering research of Nobel laureate, Dr. Otto Warburg. Seyfried’s review of the Warburg’s work is clear and compelling, even to a non-specialist, although a web search from time to time is helpful to fully grasp some of the more sophisticated concepts in biology.

The presentation and review of the author’s research as well as that of many other leading scientists provides a logical and clearly written account of the impressive body of data that continue to give validity to the “Warburg theory”. Accordingly, metabolic processes in normal and abnormal (cancerous) cells are compared with an emphasis on realistic models based largely on animal studies.

Supporting data are illustrated by figures and images that convincingly implicate metabolic dysfunction and respiratory insufficiency as the essential cause of cancer. Importantly, Seyfried then makes the strong case that it is the metabolic dysfunction that induces gene modification, now commonly recognized in virtually all cancers.

The important take home message, however, is that it is the metabolic dysfunction of the cell that drives genetic modifications-not the other way around. This is profoundly important with far reaching implications, especially for the management and prevention of cancer.

Indeed, in light of these results, it is a mystery to this reviewer why there is presently such universal focus on the genome in the development of drugs to treat what appears to be a metabolic disease. This seems to be a case of the tail wagging the dog, which would be OK, if the stakes were not so high for so many.

The last four to five chapters of the book emphasize the broader aspects of metabolic dysfunction in cancer and how an appreciation of this can lead to more humane treatments than presently is the case. The so-called “standard of care” overwhelmingly used at present emphasizes the application of poisonous drugs and toxic doses of radiation, which, as noted by the author, often engenders in patients a fear that rivals that of the disease itself.

In chapter 20 the author details the beneficial and therapeutic effects in cancer treatment of the ketogenic diet that takes full advantage of strategies logically linked to the scientific principals developed throughout the book.

I strongly recommend this book to anyone interested in the origin and treatment of cancer. It is a challenging book, but one that rewards the reader with knowledge and contemplation about one of the great plagues in modern society with every turn of the page.

*****

Well, I am interested, and I went ahead and bought the book … yes, $120.00 Canadian might seem to some to be a little steep but often in life one gets what one has paid for. I have spent at least that much and more on a good night out on the town so in the big picture it is really chump change.

I will keep you posted on how I feel about this area of research after I have read the book,  or maybe sooner if it goes slower than I expect.

Cheers

Joe

You can always find an upside even in a bad situation. Never Give Up, Never Give Up, Never Give Up!

 

Standard
Life in a small town, The Inner Struggle

Pilgrim Strangers in a Strange Land …

  早春賦, William W. Spearman IV, from the album “Beautiful Japanese Songs” (2006)

Flowing BrookSo, fasting, how are things going? So far I have been following a 1 meal a day regimen and allowing myself a 4 hour window between 6 and 10 PM for eating and snacking. Blood sugars are testing at 5.0 to 7.5 international (the conversion factor is 18 for those who want to see that in American units , eg. 7×18=126, at least that is how I think it converts) and I think that is getting close to normal, or at least a close to normal as you can measure with meter technology that is + or – 20% accurate.  Resting blood pressure is 110/60 today and weight is 234 Lbs. (or 106 Kg). I am in trace keytosis and I feel great.

(If you haven’t read my previous posts on this topic here , and here, and here, and here, and here, then let it be known that when I was diagnosed with type 2 diabetes 7 years ago I was 270 Lbs., blood sugars were in the high teens, and blood pressure was in the 140 over 90 range. I felt like crap! And for most of the last 7 years I have struggled with pills, diet, and exercise, mostly with little long term success.

In January of this year I was testing blood sugars of 16.0 to 17.0 while taking 4 Metformin and a Gliclazide daily. We were talking about starting on Insulin injections. Things were not getting better and the prognosis was not good. I started fasting in January as part of a spiritual exercise. Then good things started happening to my body. My first reaction was “What the heck is happening?” then I started digging and found Jason Fung. The rest I have blogged about.)

So back to the here and now. I have been watching a lot of videos on YouTube and some TED talks about weight loss, aging, diabetes and how to treat it and am observing that they fall into two broad categories.  The first category holds the vast majority of these presenters – who are basically using existing research (not their own) to debunk all the currently accepted or even medically recommended methods for dealing with weight loss and with “type 2 diabetes”.

This category contains all the specialists, gurus, consultants, program deliverers, diet preachers, experts, who are trying to turn sick folks away from the generally accepted practices of the medical community so that they can convert them to their “specialist” path to health.

They do not see generally accepted practices as wrong because of the bad assumptions made about causes but rather as wrong because they do not deliver results. For example, this doctor makes a pretty good presentation before he eventually sets his outrageous hook,  and he uses “medical research” from the 1920’s as his starting point.

Dr. John McDougal 2013I believe Dr. McDougall is a legitimate medical practitioner who just happens to still be living in the old “Blood Sugar is the cause” paradigm.

These Gurus without exception do not see the medically accepted practices and the people who deliver these practices as “wrong” because they have misdiagnosed the disease or misidentified the root causes but rather they see them as competitors in a marketplace.

They are pushing “Their Special Solution” as “The” only right answer, and they really want the sick folks to buy their product, or their method, or their “diet”.

The first flag that should go up when watching this category of practitioners is when you start feeling that they are spending an awful lot of time going into great depth and detail about what is wrong with everybody else’s solutions and you start wondering what their “special” solution is.

Inevitably, after they spend 3/4th of their presentation  running down their competition and dangling the bait of a miracle solution they then set the hook by presenting “their program” or “their product” and telling where you can sign up for only $19.99 U.S. per week or buy the product for “only” $49.95 or $99.95 or whatever.

A few years ago I coined a phrase “The Howler Jungle” to describe the outrageous behavior of all the raging tribes of Howler Monkeys found on Facebook. Now I have coined the new metaphor “The Snake Oil Opera” to encapsulate the legion of salesmen out there, with sometimes dubious professional credentials (because Dr. does not a doctor make).

This class of professional FUD salesmen are working their collective asses off to sell their “secret” solution to the legions of sick suckers who are always looking for an easy fix for the results of their own behavior, and who are currently mindlessly following the prevailing medical mantra about obesity and diabetes.

This FUD salesmen crowd is stuck in the same old tired, deadly, “blood sugar is the cause” paradigm that is killing fat diabetics by their thousands every year. What they are upset about is not about patients dieing, but rather it is all about who is making the money from these legions of fat diabetics. They want a slice of the pie.

“Yamanakabushi” performed by Jean-Pierre Rampal & Yuzuko Horigome, from the album “Yamanakabushi: Japanese Melodies”, Vol. 3, (1982)

Jason Fung 2017Then there is a much smaller category made up of medical and scientific researchers and practitioners who are not being funded by the Drug Companies or Big Agriculture, or Big Government and they have no special “secret Gnostic jewel” they are trying to sell to get their slice of the pie.

Examples of these presenters are Dr. Jason Fung, — ‘Therapeutic Fasting — Solving the Two-Compartment Problem’, also at The Aetiology of Obesity Part 1 of 6: A New Hope.

Dr. Jason Fung completed medical school and internal medicine at the University of Toronto before finishing his nephrology fellowship at the University of California, Los Angeles at the Cedars-Sinai hospital.

He now has a practice in Ontario, Canada where he uses his Intensive Dietary Management program to help all sorts of patients, but especially those suffering from the two big epidemics of modern times: obesity and type 2 diabetes.

Dr. Fung uses innovative solutions to these problems, realizing that conventional treatments are not that effective in helping people.

Professor Valter Longo 2017Another researcher deserving notice (IMHO) is Dr. Valter Longo .  Dr. Valter Longo is the Edna M. Jones Professor of Gerontology and Biological Sciences, and Director of the Longevity Institute at the University of Southern California – Davis School of Gerontology, Los Angeles.

Dr. Longo’s studies focus on the fundamental mechanisms of aging in simple organisms, mice and humans. The Longo laboratory has identified several genetic pathways that regulate aging in simple organisms and reduce the incidence of multiple diseases in mice and humans.

His laboratory also described both dietary and genetic interventions that protect cells and improve the treatment and prevention of cancer and other diseases in mammals.

He received his Ph.D. in Biochemistry from the University of California, Los Angeles (UCLA) in 1997,  and his postdoctoral training in the Neurobiology of Aging and Alzheimer’s Diseases at USC. He started his independent career in 2000 at the University of Southern California, School of Gerontology.

Bert Herring 2017Another doctor I believe is on the right track is Dr. Bert Herring. Originally destined for the surgical suite, Bert’s experiences in the Marine Corps changed his outlook on medicine and the realities of global problems. After working at the National Institute of Health with a focus on cancer treatments, Bert found time to study global obesity.

The outcome of this research sparked the Fast-5 weight-loss tool, which has helped thousands of people overcome obesity. It’s a way of eating that is consistent with a lifestyle emphasizing simplicity and value—two virtues that are conspicuously absent in America’s booming weight-loss industry.

In 2005, Dr. Bert showed the world a way to maintain practical, sustainable intermittent fasting with his first book, The Fast-5 Diet and the Fast-5 Lifestyle. In his latest book, AC: The Power of Appetite Correction, he’s added over a dozen tools—all sustainable lifestyle options—to help you achieve appetite correction and fat loss without calorie counting or food restrictions.

With a diverse range of experience, from the no-nonsense world of the US Marines infantry to cutting-edge cancer research at the National Institutes of Health, Dr. Bert maintains a strong sense of practicality and respect for real life.

“Life is for the living,” he says. “The way you eat has to be compatible with a life of spontaneity, fun and variety. Losing fat is almost impossible if you’re working against your body, rather than with it.”

Simplicity and value … that is really what it is all about. One unexpected benefit of our family diet is the dramatic reduction in food costs and the equally dramatic reduction in the time spent planing, shopping, preparing, cooking, eating, and cleanup. The savings are in the order of several hundred dollars a month in food costs and several hours per day which we no longer have to spend on the whole eating thing.

Canada Food GuideLastly, why have over 300 medical practitioners in Canada now signed on to a petition to health Canada to change the Canada Food Guide. These are highly intelligent, highly trained, highly professional medical practitioners. Why would they be willing to put their careers on the line to push government regulators to change the guidelines.

Is it really likely that they have all entered into some delusional episode brought on by eating too much fat and not enough carbs, or is it more likely that they are onto something important and are willing to push the truth at the risk of their professional careers.

Seriously, ask yourself what you could do with $500 to $800 a month in food and drug savings and an extra 4 or 5 hours in your day? Seriously!

Think about it!  $9000.00 dollars a year and 1500 hours a year. Couple that with vastly improved health, including complete cures for obesity, and type 2 diabetes,dramatic improvements in cardio vascular disease incidents and outcomes and cancer incidence and outcomes.  Isn’t something like that worth investigating.

Cheers

Joe

Idiots HappenWhy do people insist on continuing to believe and do things and live lifestyles which have demonstrably bad outcomes every time?

 

Standard
Life in a small town

My Atheist friend…

Had a nice visit today with a gentleman I have known for a number of years now. We get together to drink good single malt and exchange views on life and and politics and our society and the world and what we would do different.

Just a couple of fat bald old guys who have seen a lot of water go under the bridge. I remember an Irish Band from 40 years ago who were evenly split between Catholicism and Communism.  I am an orthodox Catholic and he is a self professed Atheist, and our political views are split along similar lines as the Irish band.

Makes for interesting and occasionally heated discussions, especially if it goes on long enough to get past half a bottle or so. Although we seem to disagree about almost everything except single malt and certain hobbies we enjoy each other’s company. My friend is dieing of cancer. I pray for him even though he doesn’t believe in the efficacy of prayer, or even in prayer for that matter – a lot of wishful thinking and nonsense.

I will miss him and continue to pray for his soul. Unless of course I pre-decease him … ya never know, do ya? In the end we are all brothers under the skin, whatever our views. It is only when we decide to force our views on others that we depart from the garden.

Cheers

Joe

cropped-sunrise.jpg

Disclaimer for nitpickers: We take pride in being incomplete, incorrect, inconsistent, and unfair. We do all of them deliberately.

Standard