Life in a small town

More on Cancer and Glucose … cancer and respiration …

Kojo No Tsuki” (Rentaro Taki), performed by Yo-Yo Ma, Michio Mamiya, & Patricia Zander, from the album “Japanese Melodies” (1990)

My interest in following up on “Cancer as a Metabolic Disease” is the preponderance of evidence suggesting that Cancer flourishes in a glucose rich bodily environment. Our modern western culture’s generally accepted wisdom on diet and medical care inevitably produces a glucose rich bodily environment.

Coincidentally, we seem to be experiencing an epidemic of cancer of all types with very little success in treating same with conventional treatment models. This nutritional, and medical model and the academic research interests related to these  models appear to have produced the highest disease rates for certain deadly diseases, and the lowest cure rates for those same diseases, in history. (IMAO, opinion only, not validated by research)

At the same time we have witnessed the development and proliferation of the most prestigious, prosperous and profitable sectors of health care, nutrition, government, and academia in Western history. These sectors’ prosperity is underlain by government’s ability to fund, through the use of “public” moneys, their preferred directions and interests in research, health care delivery, and manufacturing, ostensibly in the interest of “public” health, the largest sector by far of all government spending outside of compensation and benefits for government workers and management.

In nations lacking a prosperous “private” economy there is significantly less budget, less personnel at all levels, and significantly less staff and management compensation directed at these sorts of policy targets. This Western tapestry of interrelated sectors and interests is simply too large to be seriously considered as any sort of conspiracy of players, at least too large to be a human conspiracy.

Dr. Thomas N Seyfried,

Dr. Thomas N Seyfried,

However, it is hard to deny that fundamental to these developments is the modern religion of self, our modern culture of narcissism and self worship, our propensity to pursue personal prosperity and to exhibit “Me First” behaviour.

This critical conjunction of “self interest” makes it hard to imagine a better way of anonymously destroying humanity than what we are seeing taking place all around us at this time in our history.

Going along with this behaviour is a sense of: “let the “masses” look after themselves, unless there is a prospect of making revenue off them … what’s in it for me?”. Then self interest takes over as authority systems direct others … “for their own good”.

Stay on track, Joe! I have to remind myself that this is not about what is wrong and how “I” have to fix it. I have to remember that the inner struggle is about turning the sword of the imagination inward, to cut out the inner faults and bad habits, and not to turn outward to destroy the obvious evils without. Why is the default still to point out what is wrong “out there” when there is so much wrong “in here”?

So, what have I understood after getting through the first two chapters of “Cancer as a Metabolic Disease“? Well, … first of all I am always a sucker for detailed bibliographies and cited references. Here are the references pages for just Chapter 2. You can click on the images to get a larger version in another window if these are too small to read. The snippets follow …

So what have I gleaned from Chapter 1 and 2, well, here goes …

First, it became clear to me that the therapeutic action of some anticancer drugs operated largely through reduced caloric intake. Second, that reduced caloric intake could target the majority of cancer hallmarks. Third, that ketone bodies can serve as an alternative fuel to glucose in most cells with normal respiratory function. …” (Cancer as a Metabolic Disease, pp XV)

So my takeaway from this snippet is that following a carbohydrate reduced (and thus a glucose reduced), ketogenic, fat based diet, reduces the presence of glucose and increases the presence of ketone bodies, and that is good for overall health, but especially in reducing the propensity for development of cancer.

Many of the current cancer treatments exacerbate tumor cell energy metabolism, thus allowing the disease to progress and eventually become unmanageable. … The view of cancer as a genetic disease has confounded the problem and is largely responsible for the failure to develop effective therapies. The view of cancer as a genetic disease is based on the flawed notion that somatic mutations (gene mutations) cause cancer. Substantial evidence indicates that genomic instability is linked to protracted respiratory insufficiency. (ie. caused by damage to the metabolic process of cell respiration) (Cancer as a Metabolic Disease, pp XV).

In addition to the six recognized hallmarks of cancer, aerobic fermentation, or the Warburg effect is also a robust metabolic hallmark of most tumors whether they are solid or blood born. Aerobic fermentation involves elevated glucose uptake with lactic acid production in the presence of oxygen.  Elevated glucose uptake with lactic acid production is a defining characteristic of most tumors and is the basis of tumor imaging using labeled glucose analogs. … nearly all tumors depend heavily on glucose for survival.

Again, my takeaway from this is the necessity of a glucose rich environment for cancer to flourish. A ketogenic diet limits glucose levels in the body and effectively limits the possibility of cancer developing through controlling the production of glucose. Also, it is common knowledge in research circles that gene mutation is quite rare amongst healthy cells and certainly not even remotely prevalent enough to account for all the different cancers we are witnessing in the general population these days.

On the other hand, gene mutation as a result of damage to the metabolic process of cell respiration easily accounts for the frequency of cancer in all populations. It appears that the current model has the cart before the horse. It seems that there must be some other mechanism at work to support the cancer industry’s fascination with gene mutation as the primary cause of cancer.

Cancer Statistics ...

Cancer Statistics … from Cancer as a Metabolic Disease, pp 12 Chapter 1

“… Just as there are many causes of plague — heat, insects, rats, — but only one common cause, the plague bacillus, (so) there are many causes of cancer — tar, rays, arsenic, pressure, urethane, — but there is only one common cause into which all other causes of cancer merge, the irreversible injuring of respiration. An increased dependence on energy through glucose fermentation (glycolysis) was viewed as an essential compensatory mechanism of energy production for cell vitality following damage to respiration. … Warburg proposed with insight and certainty that irreversible damage to (cell) respiration was the prime cause of cancer.”

” … James Watson, who co-discovered DNA as genetic material with Francis Crick in 1953, recently suggested that more attention be paid to the metabolism of cancer. Watson also believes that the direction of cancer research in the United States is largely offtrack and misdirected at the highest levels. The absence of major clinical breakthroughs in the cancer war over the last 40 years and the death statistics … support Watson’s contention.

… the Warburg effect can be linked to impaired respiration and energy metabolism … respiratory insufficiency precedes and underlies the genome instability that accompanies tumor development. Once established, genome instability contributes to further respiratory impairment, genome mutability, and tumor progression.”

” I contend that most of the gene defects in natural cancers arise as downstream effects of damages mitochondrial function. (mitochondria are the cell organelles which enable cellular respiration). My hypothesis (Seyfried’s hypothesis) is based on evidence that genome integrity is largely dependent on the cell having sufficient mitochondrial respiration, and that all cells require regulated energy homeostasis to maintain their differentiated state.”

And thus endeth chapter the second. … more to follow as I dig deeper into this dense book.

Cheers

Joe

Rise Up

Rise Up

One of the things life has shown me is that whenever the majority of the chattering classes and the media and the academics and the government wonks are busy saying something is so, that is an almost certain indicator that it is NOT so — being on the wrong side of history is THE defining characteristic of all those opinion makers.

Standard
Life in a small town

Cancer … some more information.

From the beginning of the book  “Cancer as a Metabolic Disease …”.

… A key point made by Seyfried (Dr. Thomas Seyfried) is that most of the genomic instability seen in cancer likely arises as a consequence rather than as a cause of the disease. When viewed more as a metabolic disease, many cost effective therapeutic strategies become recognized for cancer management.

I know this first hand from our studies of 3-bromopyruvate (3BP) discovered in my laboratory by Dr. Young Ko, as a potent anticancer agent. This is a low cost drug with powerful and quick antitumor effects against multiple cancers in animal models and in cancer patients.

3BP works primarily by targeting tumor cell energy metabolism, thus depleting the energy-rich compound “ATP” essential for growth. At the effective doses used, it does this without toxicity to normal cells. 

Seyfried’s book provides substantial evidence showing how cancer can be managed using various other drugs and diets that target energy metabolism. In addition, the restriction of glucose and glutamine, which drive cancer energy metabolism, cripples the ability of cancer cells to replicate and disseminate.

Dr. Peter Pedersen

Dr. Peter Pedersen

The gene theory has deceived us into thinking that cancer is more than a single disease.” (from the Forward, by Dr. Peter Pedersen, Professor of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD)

We should note that a blog site “Science” for the magazine of the same name, reported in 2016 the following event:

“A new type of cancer drug developed at Johns Hopkins University in Baltimore, Maryland, but not yet tested in clinical trials may have triggered the deaths of three patients who were undergoing an alternative cancer treatment by a non-medical practitioner in Germany. Germany has many such practitioners, and the field is loosely regulated. The public prosecutor in Germany is now investigating whether the case constitutes involuntary manslaughter.

The drug in question, 3-Bromopyruvate (3BP), has been hailed by some researchers as a potential breakthrough, but so far the only human data about its efficacy and safety are anecdotal. Many scientists say the drug should not be administered to patients except in carefully controlled experimental settings. If the link to the three deaths is confirmed, that could cloud 3BP’s commercial prospects.”

Read the rest here.

So one might question who funds “Science” magazine. What kind of advertising do they sell? What kinds of grants do they get and from who? My take on this bad report goes like this:

Two other patients had to be treated for life-threatening conditions, the prosecutor’s office said in a press release today. Police in Germany, the Netherlands, and Belgium have urged other patients treated at the center to contact local health authorities; at least 26 have done so. Media reports suggest that cancer patients often sought Ross’s help after they ran out of conventional therapy options, or to avoid aggressive chemotherapy.”

So the patients in question had exhausted all other conventional forms of treatment. Let’s think about this situation for a minute. Unconventional 3BP treatment is linked to the deaths of 3 patients and 2 other life-threatening illnesses, … in terminal cancer patients … hmmm.

But looked at without any bias or interest, conventional chemo therapy and radiation therapy and surgery result in the eventual death of a high 90%s of all cancer patients.

Broad brushed like our MSM and popular “Science” journals like to do might lead one to look at the headline

” Candidate cancer drug suspected after death of three patients at an alternative medicine clinic. “

which inevitably leads uninformed patients towards Fear Uncertainty and Doubt, the three horsemen of the journalistic apocalypse, by which dieing people are threatened about straying off the reservation.

But with a slight adjustment and reporting of actual statistical data the same headline might read:

” Cancer drugs and Radiation Therapy suspected in death of millions of cancer patients at Private and Government Health Care Centers worldwide”

and take patients down a completely different path. That path might include a serious danger of derailing the gravy train for conventional practitioners and organizations.

There are provably more reliable statistics to support the second headline than the first, but what we hear about is the three deaths and not the millions. One is inevitably drawn to the question, yet again, of media bias and motivations.  Who are the paid shills for the establishment in this scenario?

Here is another article on 3BP

Dr Young Ko

Dr Young Ko

And this is how things went for Dr. Ko

*****

“Cancer cure found by Dr Young Ko at JHU – 3-bromopyruvate 70c per day to treat people

This is what happens to anyone who claims to have had successful research into cancer cures. Dr Ko has been sacked and her research is being “undertaken” by other scientists.

Seven years after her initial discoveries, there are no clinical trials under way, nor are there any (that I could find) that will commence any time soon. Instead, what scientists are trying to do is to make synthetic 3-bromopyruvate analogs that can be patented (and thus much more valuable).

So here we have a detour that will take years of extra research and development in order to maximize profits, while the dirt cheap, off-the-shelf chemical that could be helping people NOW gets tossed aside because it can’t be patented by a pharmaceutical company.

John’s Hopkins destroyed Dr. Ko’s career supposedly for publishing her results on 3-bromopyruvate too soon and with too much hype. Now science is proving her to be right.

Not only that, but by almost single-handedly reviving the dead concept of cancer energetics (killing cancer cells by depriving them of their unique energy needs) Dr. Ko may have made the most important single breakthrough in cancer treatment research in decades.

After destroying her for this, they now have the gall to patent her work (and under different researcher’s names). However she is taking them to court. I cant find any updates however since about 2007.”

*****

Well, one thing for sure, “Cancer as a Metabolic Disease …”. has turned into an interesting and provocative read, and there I thought it would be like reading a 4th year bio-chem textbook. Who knew?  Curiouser and curiouser …

Just thinking about it.

Your mileage may vary …

Cheers

Joe

 

Standard
Life in a small town

Cancer … and the Ketogenic diet …

WooHoo!  The Cancer book arrived today. “This book is dedicated to the millions of people who have suffered and died from toxic cancer therapies“. Just about says it all. From the Amazon.com blurb … “The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention.

It expands upon Otto Warburg’s well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the “hallmarks of cancer” and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requiring metabolic solutions for its management and prevention.

Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.”

Dr. Thomas N. Seyfried

Dr. Thomas N. Seyfried

And from the back cover … “Supported by evidence from more than 1,000 scientific and clinical studies, this groundbreaking book demonstrates that cancer is a metabolic disease and, more importantly, that it can be more effectively managed and prevented when it is recognized as such.

Moreover, the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible  for the failure to develop effective therapies and preventive strategies.

From the abstract of the article found here  at the U.S. National Library of Medicine I highlight and quote the connection to what this book is about and the Ketogenic diet as follows : “Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation.

The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The disturbances in tumor cell energy metabolism can be linked to abnormalities in the structure and function of the mitochondria.

When viewed as a mitochondrial metabolic disease, the evolutionary theory of Lamarck can better explain cancer progression than can the evolutionary theory of Darwin. Cancer growth and progression can be managed following a whole body transition from fermentable metabolites, primarily glucose and glutamine, to respiratory metabolites, primarily ketone bodies.  (this is the connection I want to shine light on between the Ketogenic diet and cancer prevention and treatment.)

As each individual is a unique metabolic entity, personalization of metabolic therapy as a broad-based cancer treatment strategy will require fine-tuning to match the therapy to an individual’s unique physiology.”

As previously posted relating to standards and guidelines, “we are all outliers” unique individuals and there is no “standard Human” to which standards and guidelines apply. Standards and guidelines are created and enforced for the convenience of practitioners and administrators, not people and patients.

It is my personal belief that the “authorities” don’t care if the “guidelines and standards” kill a few hundred thousand patients as long as they can’t be blamed, their well ordered universe is not disturbed and the gravy train is not derailed.

I am not for a minute suggesting individual personal intent in any of this. But we all want to belong to the “In Crowd”, the “right clique”, we all love ourselves and want to think of ourselves as knowing better than the rest of the mob. Peer pressure is a truly diabolical power especially amongst “professionals” whose very livelihood depends on “being on the approved list”.

My 65 years of observation seem to show that humanity is almost universally happy to ignore “truth” and “provable facts” in support of their personal “fantasy”. This is obvious with just a cursory look at everything put out by mainstream media these days.

The current “political” and “economic”polarization of our society bears daily witness to this fact. This problem with “truth” and “provable facts” is especially obvious if “truth” and “provable facts” hurt their chosen fantasy du jour, and becomes a virtual certainty if the fantasy improves their own lot in life.

The short story is we cannot live on bread alone, or cake, or candy, or rice and potatoes or a danish and a latte. We all require fine-tuning (of our diets) to match our life therapy to each individual’s unique physiology. and we cannot live without fat.

Culturally our society appears to be willingly killing ourselves with a diet high in glucose producing carbohydrates because we love our breads, sugars and starches, and we love them enough to try to eat them 6 or 8 times a day.

Many of us have become so metabolically deranged working our glucose metabolism 24/7 365 days a year that our mechanism for safely metabolising glucose has become broken – and that is how we got type 2 diabetes, and a host of other killers like cancer. “Let them eat cake” may be historically inaccurate, but it does seem to be a death sentence for us today.

Those kinds of foods are very cheap to produce and have a very high profit margin. The drugs that our current medical model prescribes to treat the resulting diseases of a cheap high carbohydrate diet have little effect in reversing and curing our current crop of medical killers and many actually create worse problems going forward.

2 Keto Dudes

2 Keto Dudes

As the 2 Keto Dudes say: “We can, however, hack our body into being full time fat burners. This hack not only allows us to maintain safe glucose levels (http://www.ncbi.nlm.nih.gov/pubmed/19099589), with less medication (http://www.ncbi.nlm.nih.gov/pubmed/25071075), but improves many of our biomarkers of disease.

If we additionally choose to use this hack to also lose weight it preserves more of our our resting energy expenditure (http://jama.jamanetwork.com/article.aspx?articleid=1199154) and over time if we have intervened early enough can allow us to reverse the progression of type 2 diabetes (http://www.yorku.ca/mriddell/documents/istype2reversible.pdf).

This dietary strategy is still something that Diabetes Associations around the world are only just now looking at, and Dietetic associations are firmly opposed to, as it is not a modest tweak of their established food pyramid, but a complete upending of it.

There are political issues as well. The USDA has a conflict of interest when it comes to dietary guidelines. That said, the ketogenic diet is quickly becoming the first approach in diabetes management among progressive medical specialists (http://www.nutritionjrnl.com/article/S0899-9007(14)00332-3/pdf).

The bottom line for us is that following the low fat model for the past 40 years has made us fatter and sicker.”

Much more to follow as I delve into this fascinating area.

Cheers

Joe

So much to study … so much to share …

Standard
Life in a small town

Diet, Micro-nutrients, and Health … Part Four


“Àki”, Rodrigo Rodriguez, from the album “Inner Thoughts” (2006)

In many ways this journey of discovery about diet and health is a story of the great courage of the leading edge practitioners who are willing to try new ideas because of results rather than simply get along, go along, with the establishment in their field because of fear.

It also requires courage and determination to take responsibility for one’s own health and life and not to simply rely upon “expert opinion”. Turns out that “expert opinion” is the same as any other opinion, and is frequently wrong.

It’s your life … you have to take responsibility for it … the path the world wants you to take is often about what’s good for them and not what’s good for you.

As mentioned previously, this post was going to be about Iodine and it’s importance but has morphed into a story of courage to try new ideas in the face of ridicule and denial. This is my continuing summary of what I have found about diet and health over the last 15 months as I searched for the Holy Grail of a cure for my Type II Diabetes and High Blood Pressure.

This is part four of my summary, and I am trying to post all this consecutively so that we can find it just by following the “Previous Posts” link at the bottom of this post. There might end up being the odd post out of sequence but mostly they are all easy to find by following the “Previous Posts” links at the end.

As previously mentioned, I am posting information and links to authors of note and to books and information sources I have found helpful in my quest. Your mileage may vary but my personal over all goal is to stay healthy, happy, and maybe get wise if I live long enough. Peace of mind in a healthy body, the synergy is unbeatable, and I believe it is all related to our diet.

I am currently personally using all the things I write about and have found them helpful in my search for a healthy lifestyle. That said, none of what I write is intended as “medical advice”, I am not a doctor nor am I any kind of medical professional.

I am just a regular Joe who has made a habit of questioning “authority” most of my life, often quietly, and often while preparing for the inevitable outcomes and disasters when we are tasked to follow through with some ill conceived plan by some superior or authority who (charitably) lacks imagination.

“Mentioned in dispatches” often happens not because of anything particularly heroic but rather because it was obvious where the situation was going and one just prepared in depth for the inevitable disaster. Best possible outcome looks pretty good after some egotistical idiot’s plan blows up in his or her face.

My daughter says I am an ENTJ according to Myers Briggs  which probably explains my personality and my tendency to be skeptical of authority and self reliant. Whatever, I just don’t believe everything “authorities” tell me is so, and the older I get the less I believe. I guess you might say, personality wise, I am “from Missouri” –  “Show Me”.

These posts on diet and health are just my reflection on my own personal experiences, what I use, the effects I have experienced, and as mentioned many times, your mileage may vary.

I have mentioned previously that my family doctor is on board and exercises oversight on my lifestyle and nutrient choices. So far he has not disagreed with anything I am doing and so far everything seems to be working out for the better. I urge anyone who is going down the path of trying this stuff out to get their doctor of choice on board with their program of health and nutrition.

This journey has been mostly about nutrition and eating and when to eat and what to eat. The results are real, but there are a lot of folks in the medical establishment who are simply knee-jerk anti diet as a fix for all the usual diseases which they prefer to treat with medications and then treat the complications from the meds with more meds and while you are at it eat lots of carbs as per the Canada Food Guide.

If you just call your diet meat and veggies all of a sudden its fine. I eat meat and veggies…doc says good! I eat Keto, doc says bad. Keto  and fasting have become a trigger word that forces many to defend or pick a side.

This way of looking at things creates a lot of cognitive dissonance in the head of both patents and old school doctors, so much so that doctors who deviate from the medical association guidelines and government guidelines are often pilloried and treated like pariahs or quacks.

It takes a tremendous amount of courage for certified medical professionals and practitioners to speak truth to power.

Often the truth will not be accepted until the generation believing the current paradigm dies out and are replaced with people who don’t have their professional ego entrenched in the current paradigm.

Absent some large personal reward, supporters of the current accepted medical paradigm will circle the wagons and revile anyone who disagrees with them. Just one example of this is reported in my last post on vested interests

We need to re-thread our heads about diet and food. So first I have a link to a 58 minute podcast from the 2 Keto Dudes. While in Perth, Australia, Richard Morris talked to Martin Cebis about the strategic dissonance in the health care system brought on by scientific findings about fat, sugar, and Diabetes.

Martin Cebis is an electronic engineer by training, with an MBA and lectures at the University of Western Australia on entrepreneurship and innovation. He is also a type 2 diabetic who reverse engineered his disease, discovered a dietary treatment using a low carbohydrate diet.

Lynne Farrow

Lynne Farrow

So, finaly, we get to today’s post on Iodine and why we need it … and why we can’t live without it.  I have just recently finished reading a book called: “The Iodine Crisis, What You Don’t Know About Iodine Can Wreck Your Life”

The author is Lynne Farrow. Her book is titled “The Iodine Crisis, What You Don’t Know About Iodine Can Wreck Your Life”. The blurb from “Goodreads is: Thanks to environmental pollutants Iodine deficiency has become a worldwide epidemic.

Everybody knows pollutants cause cancer. What they don’t know is that these pollutants cause a deficiency that can make us sick, fat and stupid.

Iodized salt–supposedly a solution to iodine deficiency– is actually a nutritional scam which provides a false sense of security.  The Iodine Crisis explains how we became so deficient, then shows the time-tested solution to reversing many conditions.

Lynne Farrow reveals how she and thousands of other patient-activists changed their lives by researching and using iodine. Frequently Asked Questions cover everything you need to know about iodine. The proof of iodine’s benefit is demonstrated by the dramatic case studies shared in this book.

So I started taking Nascent Iodine,  1 drop per day. I found further information at True Hope .  And the True Hope web site is at https://www.truehope.com/.  The information on this site has been a life saver for our family.

Here is a short excerpt from the story of Anthony Stephan  the founder of True Hope …: Ten children were left motherless the cold January day that Debbie took her own life. She had been suffering the pains of Bipolar Affective Disorder (BAD) for years and finally succumbed to the dark and irrational side of the disease.

Somehow, out of the sheer agony and crushing pain of her loss came a determination for Anthony her husband. He began a prayerful and desperate search to find hope and health for their children who were also ravaged by the disease. At the time of her death, two of Debbie’s children had also been diagnosed with BAD.

As a desperate father, and after exhausting all known medical routes, Anthony sought the help of a friend. Together these two men established a program of nutritional supplementation that would eventually lead to the recovery of Anthony’s children and the formation of The Synergy Group of Canada Inc. – a non medical research group dedicated to researching and overcoming the disorders of the central nervous system.

Debbie’s tragic death had initiated that series of events which would change the grim picture of mental illness forever. Anthony Stephan, in reflecting on the marvelous recovery of his children, said; “Truly God has answered my pleadings and intense prayers with a great blessing.” Go Read The Rest!

Well, until next time, I am now looking into diet and its connection to cancer according to some recent research by Dr. Thomas N Seyfried. Should be interesting.

Cheers

Joe

From my library, looking out over a cool rainy spring day … so much to learn, so much to share, so little time …

 

Standard