Life in a small town

More on Cancer and Glucose … cancer and respiration …

Kojo No Tsuki” (Rentaro Taki), performed by Yo-Yo Ma, Michio Mamiya, & Patricia Zander, from the album “Japanese Melodies” (1990)

My interest in following up on “Cancer as a Metabolic Disease” is the preponderance of evidence suggesting that Cancer flourishes in a glucose rich bodily environment. Our modern western culture’s generally accepted wisdom on diet and medical care inevitably produces a glucose rich bodily environment.

Coincidentally, we seem to be experiencing an epidemic of cancer of all types with very little success in treating same with conventional treatment models. This nutritional, and medical model and the academic research interests related to these  models appear to have produced the highest disease rates for certain deadly diseases, and the lowest cure rates for those same diseases, in history. (IMAO, opinion only, not validated by research)

At the same time we have witnessed the development and proliferation of the most prestigious, prosperous and profitable sectors of health care, nutrition, government, and academia in Western history. These sectors’ prosperity is underlain by government’s ability to fund, through the use of “public” moneys, their preferred directions and interests in research, health care delivery, and manufacturing, ostensibly in the interest of “public” health, the largest sector by far of all government spending outside of compensation and benefits for government workers and management.

In nations lacking a prosperous “private” economy there is significantly less budget, less personnel at all levels, and significantly less staff and management compensation directed at these sorts of policy targets. This Western tapestry of interrelated sectors and interests is simply too large to be seriously considered as any sort of conspiracy of players, at least too large to be a human conspiracy.

Dr. Thomas N Seyfried,

Dr. Thomas N Seyfried,

However, it is hard to deny that fundamental to these developments is the modern religion of self, our modern culture of narcissism and self worship, our propensity to pursue personal prosperity and to exhibit “Me First” behaviour.

This critical conjunction of “self interest” makes it hard to imagine a better way of anonymously destroying humanity than what we are seeing taking place all around us at this time in our history.

Going along with this behaviour is a sense of: “let the “masses” look after themselves, unless there is a prospect of making revenue off them … what’s in it for me?”. Then self interest takes over as authority systems direct others … “for their own good”.

Stay on track, Joe! I have to remind myself that this is not about what is wrong and how “I” have to fix it. I have to remember that the inner struggle is about turning the sword of the imagination inward, to cut out the inner faults and bad habits, and not to turn outward to destroy the obvious evils without. Why is the default still to point out what is wrong “out there” when there is so much wrong “in here”?

So, what have I understood after getting through the first two chapters of “Cancer as a Metabolic Disease“? Well, … first of all I am always a sucker for detailed bibliographies and cited references. Here are the references pages for just Chapter 2. You can click on the images to get a larger version in another window if these are too small to read. The snippets follow …

So what have I gleaned from Chapter 1 and 2, well, here goes …

First, it became clear to me that the therapeutic action of some anticancer drugs operated largely through reduced caloric intake. Second, that reduced caloric intake could target the majority of cancer hallmarks. Third, that ketone bodies can serve as an alternative fuel to glucose in most cells with normal respiratory function. …” (Cancer as a Metabolic Disease, pp XV)

So my takeaway from this snippet is that following a carbohydrate reduced (and thus a glucose reduced), ketogenic, fat based diet, reduces the presence of glucose and increases the presence of ketone bodies, and that is good for overall health, but especially in reducing the propensity for development of cancer.

Many of the current cancer treatments exacerbate tumor cell energy metabolism, thus allowing the disease to progress and eventually become unmanageable. … The view of cancer as a genetic disease has confounded the problem and is largely responsible for the failure to develop effective therapies. The view of cancer as a genetic disease is based on the flawed notion that somatic mutations (gene mutations) cause cancer. Substantial evidence indicates that genomic instability is linked to protracted respiratory insufficiency. (ie. caused by damage to the metabolic process of cell respiration) (Cancer as a Metabolic Disease, pp XV).

In addition to the six recognized hallmarks of cancer, aerobic fermentation, or the Warburg effect is also a robust metabolic hallmark of most tumors whether they are solid or blood born. Aerobic fermentation involves elevated glucose uptake with lactic acid production in the presence of oxygen.  Elevated glucose uptake with lactic acid production is a defining characteristic of most tumors and is the basis of tumor imaging using labeled glucose analogs. … nearly all tumors depend heavily on glucose for survival.

Again, my takeaway from this is the necessity of a glucose rich environment for cancer to flourish. A ketogenic diet limits glucose levels in the body and effectively limits the possibility of cancer developing through controlling the production of glucose. Also, it is common knowledge in research circles that gene mutation is quite rare amongst healthy cells and certainly not even remotely prevalent enough to account for all the different cancers we are witnessing in the general population these days.

On the other hand, gene mutation as a result of damage to the metabolic process of cell respiration easily accounts for the frequency of cancer in all populations. It appears that the current model has the cart before the horse. It seems that there must be some other mechanism at work to support the cancer industry’s fascination with gene mutation as the primary cause of cancer.

Cancer Statistics ...

Cancer Statistics … from Cancer as a Metabolic Disease, pp 12 Chapter 1

“… Just as there are many causes of plague — heat, insects, rats, — but only one common cause, the plague bacillus, (so) there are many causes of cancer — tar, rays, arsenic, pressure, urethane, — but there is only one common cause into which all other causes of cancer merge, the irreversible injuring of respiration. An increased dependence on energy through glucose fermentation (glycolysis) was viewed as an essential compensatory mechanism of energy production for cell vitality following damage to respiration. … Warburg proposed with insight and certainty that irreversible damage to (cell) respiration was the prime cause of cancer.”

” … James Watson, who co-discovered DNA as genetic material with Francis Crick in 1953, recently suggested that more attention be paid to the metabolism of cancer. Watson also believes that the direction of cancer research in the United States is largely offtrack and misdirected at the highest levels. The absence of major clinical breakthroughs in the cancer war over the last 40 years and the death statistics … support Watson’s contention.

… the Warburg effect can be linked to impaired respiration and energy metabolism … respiratory insufficiency precedes and underlies the genome instability that accompanies tumor development. Once established, genome instability contributes to further respiratory impairment, genome mutability, and tumor progression.”

” I contend that most of the gene defects in natural cancers arise as downstream effects of damages mitochondrial function. (mitochondria are the cell organelles which enable cellular respiration). My hypothesis (Seyfried’s hypothesis) is based on evidence that genome integrity is largely dependent on the cell having sufficient mitochondrial respiration, and that all cells require regulated energy homeostasis to maintain their differentiated state.”

And thus endeth chapter the second. … more to follow as I dig deeper into this dense book.

Cheers

Joe

Rise Up

Rise Up

One of the things life has shown me is that whenever the majority of the chattering classes and the media and the academics and the government wonks are busy saying something is so, that is an almost certain indicator that it is NOT so — being on the wrong side of history is THE defining characteristic of all those opinion makers.

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Life in a small town

Cancer … and the Ketogenic diet …

WooHoo!  The Cancer book arrived today. “This book is dedicated to the millions of people who have suffered and died from toxic cancer therapies“. Just about says it all. From the Amazon.com blurb … “The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention.

It expands upon Otto Warburg’s well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the “hallmarks of cancer” and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requiring metabolic solutions for its management and prevention.

Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.”

Dr. Thomas N. Seyfried

Dr. Thomas N. Seyfried

And from the back cover … “Supported by evidence from more than 1,000 scientific and clinical studies, this groundbreaking book demonstrates that cancer is a metabolic disease and, more importantly, that it can be more effectively managed and prevented when it is recognized as such.

Moreover, the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible  for the failure to develop effective therapies and preventive strategies.

From the abstract of the article found here  at the U.S. National Library of Medicine I highlight and quote the connection to what this book is about and the Ketogenic diet as follows : “Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation.

The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The disturbances in tumor cell energy metabolism can be linked to abnormalities in the structure and function of the mitochondria.

When viewed as a mitochondrial metabolic disease, the evolutionary theory of Lamarck can better explain cancer progression than can the evolutionary theory of Darwin. Cancer growth and progression can be managed following a whole body transition from fermentable metabolites, primarily glucose and glutamine, to respiratory metabolites, primarily ketone bodies.  (this is the connection I want to shine light on between the Ketogenic diet and cancer prevention and treatment.)

As each individual is a unique metabolic entity, personalization of metabolic therapy as a broad-based cancer treatment strategy will require fine-tuning to match the therapy to an individual’s unique physiology.”

As previously posted relating to standards and guidelines, “we are all outliers” unique individuals and there is no “standard Human” to which standards and guidelines apply. Standards and guidelines are created and enforced for the convenience of practitioners and administrators, not people and patients.

It is my personal belief that the “authorities” don’t care if the “guidelines and standards” kill a few hundred thousand patients as long as they can’t be blamed, their well ordered universe is not disturbed and the gravy train is not derailed.

I am not for a minute suggesting individual personal intent in any of this. But we all want to belong to the “In Crowd”, the “right clique”, we all love ourselves and want to think of ourselves as knowing better than the rest of the mob. Peer pressure is a truly diabolical power especially amongst “professionals” whose very livelihood depends on “being on the approved list”.

My 65 years of observation seem to show that humanity is almost universally happy to ignore “truth” and “provable facts” in support of their personal “fantasy”. This is obvious with just a cursory look at everything put out by mainstream media these days.

The current “political” and “economic”polarization of our society bears daily witness to this fact. This problem with “truth” and “provable facts” is especially obvious if “truth” and “provable facts” hurt their chosen fantasy du jour, and becomes a virtual certainty if the fantasy improves their own lot in life.

The short story is we cannot live on bread alone, or cake, or candy, or rice and potatoes or a danish and a latte. We all require fine-tuning (of our diets) to match our life therapy to each individual’s unique physiology. and we cannot live without fat.

Culturally our society appears to be willingly killing ourselves with a diet high in glucose producing carbohydrates because we love our breads, sugars and starches, and we love them enough to try to eat them 6 or 8 times a day.

Many of us have become so metabolically deranged working our glucose metabolism 24/7 365 days a year that our mechanism for safely metabolising glucose has become broken – and that is how we got type 2 diabetes, and a host of other killers like cancer. “Let them eat cake” may be historically inaccurate, but it does seem to be a death sentence for us today.

Those kinds of foods are very cheap to produce and have a very high profit margin. The drugs that our current medical model prescribes to treat the resulting diseases of a cheap high carbohydrate diet have little effect in reversing and curing our current crop of medical killers and many actually create worse problems going forward.

2 Keto Dudes

2 Keto Dudes

As the 2 Keto Dudes say: “We can, however, hack our body into being full time fat burners. This hack not only allows us to maintain safe glucose levels (http://www.ncbi.nlm.nih.gov/pubmed/19099589), with less medication (http://www.ncbi.nlm.nih.gov/pubmed/25071075), but improves many of our biomarkers of disease.

If we additionally choose to use this hack to also lose weight it preserves more of our our resting energy expenditure (http://jama.jamanetwork.com/article.aspx?articleid=1199154) and over time if we have intervened early enough can allow us to reverse the progression of type 2 diabetes (http://www.yorku.ca/mriddell/documents/istype2reversible.pdf).

This dietary strategy is still something that Diabetes Associations around the world are only just now looking at, and Dietetic associations are firmly opposed to, as it is not a modest tweak of their established food pyramid, but a complete upending of it.

There are political issues as well. The USDA has a conflict of interest when it comes to dietary guidelines. That said, the ketogenic diet is quickly becoming the first approach in diabetes management among progressive medical specialists (http://www.nutritionjrnl.com/article/S0899-9007(14)00332-3/pdf).

The bottom line for us is that following the low fat model for the past 40 years has made us fatter and sicker.”

Much more to follow as I delve into this fascinating area.

Cheers

Joe

So much to study … so much to share …

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